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The final clinically important outcome is destruction of red cells, which is both intravascular (witness haemoglobinuria) and extravascular [witness hyperbilirubinaemia (Fischer et al , 1985)]

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In addition to the methods recommended by the FDA and OECD, high-throughput and standardized BAT and LTT methods can quickly deliver information to hint at the possibility of ADHRs induced by drug-specific IgE or T cells, which could be acceptable in preclinical hypersensitivity testing